4 edition of Characterization of the trophic properties of GLP-2, a novel intestinal growth factor found in the catalog.
Characterization of the trophic properties of GLP-2, a novel intestinal growth factor
Anne Chun-Hui Tsai
Thesis (M.Sc.) -- University of Toronto, 1996.
|Series||Canadian theses = -- Thèses canadiennes|
|The Physical Object|
|Pagination||2 microfiches : negative. --|
Toggle navigation. Home; Topics. VIEW ALL TOPICS. The potential role of mitochondrial ATP synthase inhibitory factor 1 (IF1) in coronary heart disease: a literature review - , Lipids in Health and Dise 1, /s
ESP: PubMed Auto Bibliography 26 May at Created: Microbiome. It has long been known that every multicellular organism coexists with large prokaryotic ecosystems — mi. World Health Organization Classification of Tumours.
The present invention relates to extended recombinant polypeptide (XTEN) compositions, conjugate compositions comprising XTEN and XTEN linked to cross-linkers useful for conjugation to pharmacologically active payloads, methods of making highly purified XTEN, methods of making XTEN-linker and XTEN-payload conjugates, and methods of using the XTEN-cross-linker and XTEN-payload . Association Between Prior Diagnosis of an ABA or NSAID-Requldng Condition and Esophageal Cancer Condition OR 95% C,L Acute Myocardial infarction Ischemlc Heart Disease 0~72 Rheumatoid arthritis Osteoarthdtis Any ASA or NSAID-Requiring Condition 0,74 Any ABA-requiring Condition ~79 Any NSAID-requidng Condition .
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Analyses of mechanisms mediating GLP-2 action in the small and large intestine have employed receptor antagonists, immunoneutralizing antisera, and knockout mice. To date, keratinocyte growth factor, IGF-I, and members of the ErbB superfamily have been implicated as growth factors transducing the proliferative effects of GLP-2 in the gut (20 Cited by: Lipidation did, however, not affect the intestinotrophic properties of GLP-1 ad GLP-2 co-agonism and both GUB and GUB led to a marked up to 70% increase in small intestinal mass (GUB 50 nmol/kg BID 60 ± %, GUB 50 nmol/kg BID 72 ± %, Fig.
6E), whereas no significant effect was observed in colon volume (Fig. 6F Cited by: 6. GLP-2 induced a significant increase in SB weight ( to fold increase over control, P Cited by: These novel dual-acting peptides have highlighted possible synergistic effects of combining GLP-1 agonism with other gastrointestinal hormones as an effective treatment of T2D and/or obesity.
Administration of gastrin in combination with epidermal growth factor, GLP-1, or exendin-4Cited by: The question is of interest in the context of colon cancer, because GLP-2 stimulates normal colonic, as well as small intestinal, growth  and reduces injury in a mouse model of colitis [ Request PDF | On Jan 1,R.
Just and others published The novel GLPGLP-2 dual agonist ZP-GG increases intestinal growth and improves insulin sensitivity in DIO mice | Find, read and Author: Rasmus Just.
The role of the GLP-2 receptor in intestinal and islet adaptation to changes in nutrient availability Jasmine Bahrami Doctor of Philosophy Institute of Medical Science University of Toronto ABSTRACT GLP-2 is a potent intestinotrophic peptide that can increase mucosal growth, intestinalAuthor: Jasmine Bahrami.
GLP 2 has not been shown to have any effect on food intake in humans. GLP-2 has not been shown to be critical in the development of fetal intestine, but does contribute to neonatal intestinal growth.
Rats lacking GLP-2 due to a mutation, exhibited normal growth of the bowels. Therapeutic implications of GLP Exendin-4 (Ex-4), one of the important glucagon-like peptide-1 receptor (GLP-1R) agonists, has proven to be an effective antidiabetic agent for type 2 diabetes (T2D).
However, its therapeutic potential is limited due to its short half-life (t1/2), which is subcutaneously administered twice daily.
The aim of this stCited by: 1. Min Kyun Park, in Handbook of Hormones, Structure and Subtypes. The human GLP-2 receptor gene (GLP2R) is located on chromosome 17 (17p), and the human and rat GLP-2 receptor cDNAs were cloned from intestinal and hypothalamic cDNA libraries in .The rat GLP-2 cDNA comprises 2, bp and encodes an open reading frame of a aa precursor.
Abstract. Adaptation of the residual small bowel following resection is dependent on luminal and humoral factors. We aimed to establish if circulating levels of glucagon-like peptide (GLP-2) change under different dietary regimens following resection and to determine if there is a relationship between plasma GLP-2 levels and markers of intestinal by: Novel Long‐Acting GLP‐2 Analogue, FE (Apraglutide), Enhances Adaptation and Linear Intestinal Growth in a Neonatal Piglet Model of Short Cited by: Effect of the Enteric Hormone Glucagon-Like Peptide (GLP-2) on the Intestinal Blood Flow in Patients With Short Bowel Syndrome The safety and scientific validity of this study is the responsibility of the study sponsor and investigators.
Geurts L, Neyrinck AM, Delzenne NM, Knauf C, Cani PD. Gut microbiota controls adipose tissue expansion, gut barrier and glucose metabolism: novel insights into molecular targets and interventions using prebiotics.
Beneficial microbes. – doi: /BMCited by: Abstract (summary): GLP-2 is a potent intestinotrophic peptide that can increase mucosal growth, intestinal blood flow, and nutrient absorption when administered exogenously. We aimed to delineate the effects of endogenous GLP-2R signalling in conditions of nutrient deprivation and excess.
Using a mouse with a targeted genetic deletion of the Glp2r gene (Glp2r-/-), we addressed the hypothesis Author: Jasmine Bahrami. ↓ Intestinal motility and validated the specificity of a highly sensitive and specific MAb and have applied this antibody in a thorough characterization of primate GLP-1 target organs.
In the case of the pancreas, previous data were essentially confirmed but careful evaluation of GI, cardiac, and renal tissues revealed completely novel Cited by: The present invention generally treats metabolic diseases and conditions such as those that can be alleviated by controlling plasma glucose levels, insulin levels, and / or insulin secretion, positive inotropic effects, reducing catabolic effects, slowing gastric emptying and It relates to novel GIP analogs useful as prophylactic agents and GIP hybrid polypeptides with selectable : アラン・ディ・バロン, アンドリュー・エイ・ヤング, オディール・エスター・レビー, キャロリン・エム・ジョドカ, クリスティーン・エム・マック, クリストファー・ジェイ・ソアレス, サミュエル・ヤン.
Cardiovascular diseases (CVD) are still the prevailing cause of death not only in industrialized countries, but even worldwide. Type 2 diabetes mellitus (type 2 DM) and hyperlipidemia, a metabolic disorder that is often associated with diabetes, are major risk factors for developing CVD.
Recently, clinical trials proved the safety of gliptins in treating patients with type 2 by: 2. Louveau I, Gondret F. Regulation of development and metabolism of adipose tissue by growth hormone and the insulin-like growth factor system.
Domest Anim Endocrinol ; Although the HPA and HPT axes have been more closely scrutinized in patients with psychiatric disorders, there is virtual universal agreement that the blunted growth-hormone response to a variety of provocative stimuli (particularly clonidine, an a 2-adrenergic agonist) in depressed patients is the most consistent finding in affective disorders research.(29) The mechanism underlying this /5.
The complex polymicrobial composition of human gut microbiota plays a key role in health and disease. Lachnospiraceae belong to the core of gut microbiota, colonizing the intestinal lumen from birth and increasing, in terms of species richness and their relative abundances during the host’s life.
Although, members of Lachnospiraceae are among the main producers of short-chain fatty acids.Cells of the Human Body (of seminal vesicle, prostate gland, etc.) Intestinal brush border cell (with microvilli) Exocrine gland striated duct cell Gall bladder epithelial cell Ductulus efferens nonciliated cell Epididymal principal cell Epididymal basal cell Important players include beta-1 integrin, epidermal growth factor receptor.Nat.
Genet. ; – Stoetzel C, Muller J, Laurier V, et al. Identification of a novel BBS gene (BBS12) highlights the major role of a vertebrate-specific branch of chaperonin-related proteins in Bardet-Biedl syndrome. Am. J. Hum. Genet. ; – Katsanis N. The oligogenic properties of Bardet-Biedl syndrome.